General Information of This Metabolic Reaction (MR) (ID: MR012030)
Formula Reactant Fruquintinib Product M205
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012015 Fruquintinib M379-1 Unclear - Unclear fruquintinib [1], [2]
MR012019 Fruquintinib M379-2 Oxidation - O-desmethylation fruquintinib [3]
MR012028 Fruquintinib M380 Unclear - Unclear fruquintinib [4]
MR012034 Fruquintinib M409-1 Unclear - Unclear fruquintinib [5], [2]
MR012023 Fruquintinib M409-2 Oxidation - Mono-oxidation fruquintinib [6], [2]
MR012010 Fruquintinib M409-3 Oxidation - Mono-oxidation fruquintinib [7]
MR012033 Fruquintinib M409-4 Oxidation - Mono-oxidation fruquintinib [8], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012031 M205 M285 Conjugation - Sulfation fruquintinib [9]
MR012032 M205 M381 Conjugation - Glucuronidation fruquintinib [10]
References
1 Incarceration of the medial collateral ligament in the intercondylar notch following proximal avulsion
2 Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
3 Internal resources among informal caregivers: trajectories and associations with well-being
4 Spontaneous thrombosis of a giant cerebral varix in a pediatric patient
5 Esophageal bezoar due to karaya gum granules used as a laxative
6 A simple and rapid infrared-assisted self enzymolysis extraction method for total flavonoid aglycones extraction from Scutellariae Radix and mechanism exploration
7 A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [(14)C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers
8 Management of postoperative junctional ectopic tachycardia in pediatric patients: a survey of 30 centers in Germany, Austria, and Switzerland
9 Assessment of hepatitis B virus antibody titers in childhood cancer survivors
10 Renal function in neonates with twin-twin transfusion syndrome treated with or without fetoscopic laser surgery

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