General Information of This Metabolic Reaction (MR) (ID: MR012015)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Fruquintinib Product M379-1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012030 Fruquintinib M205 Unclear - Unclear fruquintinib [1]
MR012019 Fruquintinib M379-2 Oxidation - O-desmethylation fruquintinib [2]
MR012028 Fruquintinib M380 Unclear - Unclear fruquintinib [3]
MR012034 Fruquintinib M409-1 Unclear - Unclear fruquintinib [4], [5]
MR012023 Fruquintinib M409-2 Oxidation - Mono-oxidation fruquintinib [6], [5]
MR012010 Fruquintinib M409-3 Oxidation - Mono-oxidation fruquintinib [7]
MR012033 Fruquintinib M409-4 Oxidation - Mono-oxidation fruquintinib [8], [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012017 M379-1 M365-1 Unclear - Unclear fruquintinib [9]
MR012016 M379-1 M365-2/3 Unclear - Unclear fruquintinib [10]
MR012018 M379-1 M555-1 Unclear - Unclear fruquintinib [11]
References
1 Locus coeruleus neuronal activity correlates with behavioral response to acute and chronic doses of methylphenidate (Ritalin) in adolescent rats
2 Internal resources among informal caregivers: trajectories and associations with well-being
3 Spontaneous thrombosis of a giant cerebral varix in a pediatric patient
4 Esophageal bezoar due to karaya gum granules used as a laxative
5 Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
6 A simple and rapid infrared-assisted self enzymolysis extraction method for total flavonoid aglycones extraction from Scutellariae Radix and mechanism exploration
7 A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [(14)C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers
8 Management of postoperative junctional ectopic tachycardia in pediatric patients: a survey of 30 centers in Germany, Austria, and Switzerland
9 Prophylactic etanercept treatment in cisplatin ototoxicity
10 Early computed tomography or focused assessment with sonography in abdominal trauma: what are the leading opinions?
11 Biopsychosocial factors predict quality of life in thoracolumbar spine surgery

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