Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012851)
Formula
SVG example
Reactant Androstenedione Product Testosterone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012847 Androstenedione 11beta-hydroxyandrostenedione Unclear Androstenedione [1]
MR012852 Androstenedione 5alpha-dihydroandrostenedione Unclear Androstenedione [2]
MR012850 Androstenedione 5alpha-dihydrotestosterone Unclear Androstenedione [2]
MR012849 Androstenedione 6beta-hydroxy-androstenedione Oxidation - Aliphatic hydroxylation Androstenedione [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004534 AC-12166 Testosterone Unclear AC-12166 [4], [5]
MR004896 Testosterone cypionate Testosterone Hydrolysis - Hydrolyation Testosterone cypionate [6]
MR009623 Testosterone enanthate Testosterone Hydrolysis - Hydrolysis Testosterone enanthate [7]
MR004897 Testosterone undecanoate Testosterone Hydrolysis - Esterase hydrolyzation Testosterone undecanoate [8]
MR003146 4-androstene-3,17-dione(AD) Testosterone Unclear Dehydroepiandrosterone [9]
MR009027 Androst-4-ene-3,17-dione(4-Adione) Testosterone Unclear - Unclear EPIANDROSTERONE [10]
MR005803 Dehydroepiandrosterone Testosterone Unclear Prasterone sulfate [11]
⏷ Show the Full List of MR
References
1 11-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5-reductase yielding 11-hydroxy-5-androstanedione
2 Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences
3 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
4 Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat
5 Conversion of 4-androstenediol and 5-androstenediol to testosterone, and conversion of dehydroepiandrosterone to 4-androstenediol by rat testis in vitro
6 The history of synthetic testosterone
7 LABEL: Testosterone enanthate
8 Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials
9 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.
10 Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports
11 Toxin and Toxin Target Database (T3DB):Prasterone sulfate

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