Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012849)
Formula
SVG example
Aliphatic hydroxylation
Reactant Androstenedione Product 6beta-hydroxy-androstenedione
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012847 Androstenedione 11beta-hydroxyandrostenedione Unclear Androstenedione [1]
MR012852 Androstenedione 5alpha-dihydroandrostenedione Unclear Androstenedione [2]
MR012850 Androstenedione 5alpha-dihydrotestosterone Unclear Androstenedione [2]
MR012851 Androstenedione Testosterone Unclear Androstenedione [2]
References
1 11-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5-reductase yielding 11-hydroxy-5-androstanedione
2 Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences

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