Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012907)
Formula
CYP3A4 ...
SVG example
Reactant Cyclobenzaprine Product Dechloroethyl cyclophosphamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [1], [2]
MR012908 Cyclobenzaprine Chloroacetaldehyde Unclear Cyclobenzaprine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009948 Cyclophosphamide Dechloroethyl cyclophosphamide Unclear - Unclear Cyclophosphamide [2]
MR004662 Ifosfamide 3-Dechloroethylifosfamide Unclear Ifosfamide [4], [1]
References
1 The KEGG resource for deciphering the genome
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 U. S. FDA Label -Cyclobenzaprine
4 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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