Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012897)
Formula
CYP2C9 ...
SVG example
4-hydroxylation
Reactant Cyclobenzaprine Product 4-Hydroxycyclophosphamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - 4-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012908 Cyclobenzaprine Chloroacetaldehyde Unclear Cyclobenzaprine [1]
MR012907 Cyclobenzaprine Dechloroethyl cyclophosphamide Unclear Cyclobenzaprine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009942 Cyclophosphamide 4-Hydroxycyclophosphamide Unclear - Unclear Cyclophosphamide [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009947 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear - Unclear Cyclophosphamide [3]
MR012906 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear Cyclobenzaprine [1]
MR009943 4-Hydroxycyclophosphamide Aldophosphamide Unclear - Unclear Cyclophosphamide [3]
MR012898 4-Hydroxycyclophosphamide Aldophosphamide Unclear Cyclobenzaprine [3]
References
1 U. S. FDA Label -Cyclobenzaprine
2 Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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