Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004662)
Formula
CYP3A4 ...
SVG example
Reactant Ifosfamide Product 3-Dechloroethylifosfamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004650 Ifosfamide 4-Hydroxyifosfamide Oxidation - 4-hydroxylation Ifosfamide [1]
MR004660 Ifosfamide Chloroacetaldehyde Unclear Ifosfamide [1], [2]
MR004663 Ifosfamide Dechloroethylifosfamide Unclear Ifosfamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012907 Cyclobenzaprine Dechloroethyl cyclophosphamide Unclear Cyclobenzaprine [3]
MR009948 Cyclophosphamide Dechloroethyl cyclophosphamide Unclear - Unclear Cyclophosphamide [4]
References
1 The KEGG resource for deciphering the genome
2 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity
3 U. S. FDA Label -Cyclobenzaprine
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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