Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013046)
Formula
CYP2C19 ...
SVG example
N-demethylation
Reactant Ranitidine Product Desmethylranitidine
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013047 Ranitidine Ranitidine N-Oxide Oxidation - N-oxygenation Ranitidine [1]
MR013048 Ranitidine Ranitidine S-Oxide Oxidation - S-oxygenation Ranitidine [1]
References
1 Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. Jpn J Pharmacol. 2000 Oct;84(2):213-20.

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