Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013052)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Repaglinide Product Repaglinide M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013051 Repaglinide Hydroxyrepaglinide Oxidation - Hydroxylation Repaglinide [1]
MR013055 Repaglinide Repaglinide M0-OH Oxidation - Hydroxylation Repaglinide [2]
MR013049 Repaglinide Repaglinide M2 Unclear - Unclear Repaglinide [1], [3]
MR013053 Repaglinide Repaglinide M5 Unclear - Unclear Repaglinide [2]
MR013054 Repaglinide Repaglinide M7 Conjugation - Glucuronidation Repaglinide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013050 Repaglinide M2 Repaglinide M1 Oxidation - Oxidation Repaglinide [1]
References
1 Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide
2 Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism. Br J Clin Pharmacol. 2010 Dec;70(6):870-80.
3 Bioanalytical method for in vitro metabolism study of repaglinide using 96-blade thin-film solid-phase microextraction and LC-MS/MS

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