Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013053)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Repaglinide Product Repaglinide M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013051 Repaglinide Hydroxyrepaglinide Oxidation - Hydroxylation Repaglinide [1]
MR013055 Repaglinide Repaglinide M0-OH Oxidation - Hydroxylation Repaglinide [2]
MR013052 Repaglinide Repaglinide M1 Oxidation - Oxidation Repaglinide [1], [3]
MR013049 Repaglinide Repaglinide M2 Unclear - Unclear Repaglinide [1], [3]
MR013054 Repaglinide Repaglinide M7 Conjugation - Glucuronidation Repaglinide [2]
References
1 Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide
2 Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism. Br J Clin Pharmacol. 2010 Dec;70(6):870-80.
3 Bioanalytical method for in vitro metabolism study of repaglinide using 96-blade thin-film solid-phase microextraction and LC-MS/MS

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