Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013079)
Formula
CYP2B6 ...
SVG example
N-demethylation
Reactant Vonoprazan Product N-demethylated TAK-438
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013077 Vonoprazan TAK-438 N-sulfate Oxidation - Sulfonation Vonoprazan [1], [2]
MR013073 Vonoprazan Vonoprazan M- Unclear - Unclear Vonoprazan [1], [2]
MR013080 Vonoprazan Vonoprazan M- Unclear - Unclear Vonoprazan [1], [2]
References
1 Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date
2 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.

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