Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013073)
Formula
CYP2B6 ...
SVG example
Unclear
Reactant Vonoprazan Product Vonoprazan M-
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013079 Vonoprazan N-demethylated TAK-438 Oxidation - N-demethylation Vonoprazan [1], [2]
MR013077 Vonoprazan TAK-438 N-sulfate Oxidation - Sulfonation Vonoprazan [3], [2]
MR013080 Vonoprazan Vonoprazan M- Unclear - Unclear Vonoprazan [3], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013074 Vonoprazan M- Vonoprazan M- Unclear - Unclear Vonoprazan [3]
MR013076 Vonoprazan M- Vonoprazan M--G Conjugation - Glucuronidation Vonoprazan [3]
References
1 Assessments of CYP?inhibition?based drug-drug interaction between vonoprazan and poziotinib in?vitro and in?vivo
2 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.
3 Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

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