Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013304)
Formula Reactant Cinnarizine Product Cinnarizine metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013307 Cinnarizine 1-Cinnamylpiperazine Oxidation - N-dealkylation; hydrolysis Cinnarizine [1]
MR013306 Cinnarizine Cinnamaldehyde Oxidation - N-dealkylation Cinnarizine [1]
MR013303 Cinnarizine Cinnarizine metabolite M1 Unclear Cinnarizine [2]
MR013305 Cinnarizine Cinnarizine metabolite M4 Oxidation - Hydrolyzationn Cinnarizine [2]
References
1 DrugBank : Cinnarizine
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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