Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013306)
Formula
CYP2C9 ...
SVG example
N-dealkylation
Reactant Cinnarizine Product Cinnamaldehyde
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013307 Cinnarizine 1-Cinnamylpiperazine Oxidation - N-dealkylation; hydrolysis Cinnarizine [1]
MR013303 Cinnarizine Cinnarizine metabolite M1 Unclear Cinnarizine [2]
MR013304 Cinnarizine Cinnarizine metabolite M2 Oxidation - Hydrolyzationn Cinnarizine [2]
MR013305 Cinnarizine Cinnarizine metabolite M4 Oxidation - Hydrolyzationn Cinnarizine [2]
References
1 DrugBank : Cinnarizine
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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