Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013395)
Formula Reactant Metoclopramide hydrochloride Product Metoclopramide hydrochloride Metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013398 Metoclopramide hydrochloride Metoclopramide Conjugated metabolite Conjugation - Sulfation Metoclopramide hydrochloride [1], [2]
MR013399 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M1 Multi-steps Reaction - Oxidationn; followed by glucuronidation Metoclopramide hydrochloride [3]
MR013406 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M10 Oxidation - Nitration Metoclopramide hydrochloride [3]
MR013400 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M2 Conjugation - Sulfonylation Metoclopramide hydrochloride [3]
MR013401 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M3 Oxidation - N-dealkylation Metoclopramide hydrochloride [3]
MR013402 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M5 Unclear Metoclopramide hydrochloride [3]
MR013403 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M6 Unclear Metoclopramide hydrochloride [3]
MR013404 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M7 Conjugation - Glucuronidation Metoclopramide hydrochloride [3]
MR013405 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M9 Other reaction - N-carbamoylation Metoclopramide hydrochloride [3]
MR013397 Metoclopramide hydrochloride Monodeethylmetoclopramide Unclear Metoclopramide hydrochloride [4], [5], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013396 Metoclopramide hydrochloride Metabolite M4 Metoclopramide hydrochloride Metabolite M6 Other reaction - Oxidationn followed by glucuronidation Metoclopramide hydrochloride [3]
References
1 Clinical pharmacokinetics of metoclopramide
2 Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319.
3 Identification of novel metoclopramide metabolites in humans: in vitro and in vivo studies
4 The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6. Drug Metab Dispos. 2002 Mar;30(3):336-43.
5 Lessons from pharmacogenetics and metoclopramide: toward the right dose of the right drug for the right patient. J Clin Gastroenterol. 2012 Jul;46(6):437-9.

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