Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013469)
Formula Reactant Etoperidone Product 1-(3-chlorophenyl) piperazine (M22)
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013453 Etoperidone 1-(3-chlorophenyl) piperazine Unclear Etoperidone [1], [2]
MR013460 Etoperidone Etoperidone Metabolite M12 Hydrolysis - Hydrolysis Etoperidone [1]
MR013465 Etoperidone Etoperidone Metabolite M19 Oxidation - Oxidationn Etoperidone [1]
MR013442 Etoperidone Etoperidone Metabolite M2 Oxidation - Oxidationn Etoperidone [1], [2]
MR013466 Etoperidone Etoperidone Metabolite M20 Oxidation - Oxidationn Etoperidone [1]
MR013467 Etoperidone Etoperidone Metabolite M21 Oxidation - Oxidationn Etoperidone [1]
MR013468 Etoperidone Etoperidone Metabolite M4 Oxidation - Aromatic hydroxylation Etoperidone [1]
MR013451 Etoperidone Etoperidone Metabolite M5 Oxidation - Hydrolyzationn Etoperidone [1], [2]
MR013458 Etoperidone Etoperidone Metabolite M6 Oxidation - N-dealkylation Etoperidone [1]
MR013455 Etoperidone Etoperidone Metabolite N6 Unclear Etoperidone [1]
MR013464 Etoperidone N-oxide etoperidone Oxidation - Oxidationn Etoperidone [1]
References
1 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
2 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.

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