Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013651)
Formula Reactant PT2385 Product PT2385 M8
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronide conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013648 PT2385 PT2385 M10 Oxidation - Hydroxylation PT2385 [1]
MR013646 PT2385 PT2385 M2 Oxidation - Hydroxylation PT2385 [1]
MR013644 PT2385 PT2385 M3,M4 Multi-steps Reaction - Hydroxylation; Desaturation PT2385 [1]
MR013642 PT2385 PT2385 M7 Oxidation - Oxidative Defluorination PT2385 [1]
MR013650 PT2385 PT2385 M9 Conjugation - N-acetylcysteine conjugation PT2385 [1]
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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