Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013642)
Formula
CYP2C19 ...
SVG example
Oxidative Defluorination
Reactant PT2385 Product PT2385 M7
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Oxidative Defluorination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013648 PT2385 PT2385 M10 Oxidation - Hydroxylation PT2385 [1]
MR013646 PT2385 PT2385 M2 Oxidation - Hydroxylation PT2385 [1]
MR013644 PT2385 PT2385 M3,M4 Multi-steps Reaction - Hydroxylation; Desaturation PT2385 [1]
MR013651 PT2385 PT2385 M8 Conjugation - Glucuronide conjugation PT2385 [1]
MR013650 PT2385 PT2385 M9 Conjugation - N-acetylcysteine conjugation PT2385 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013643 PT2385 M7 PT2385 M12 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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