Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013646)
Formula Reactant PT2385 Product PT2385 M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013648 PT2385 PT2385 M10 Oxidation - Hydroxylation PT2385 [1]
MR013644 PT2385 PT2385 M3,M4 Multi-steps Reaction - Hydroxylation; Desaturation PT2385 [1]
MR013642 PT2385 PT2385 M7 Oxidation - Oxidative Defluorination PT2385 [1]
MR013651 PT2385 PT2385 M8 Conjugation - Glucuronide conjugation PT2385 [1]
MR013650 PT2385 PT2385 M9 Conjugation - N-acetylcysteine conjugation PT2385 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013647 PT2385 M2 PT2385 M11 Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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