Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013689)
Formula Reactant Indocyanine green Product Carboxyl metabolite enzalutamide (M1)
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Metabolic Type Multi-steps Reaction - Amide Hydrolysis; Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013685 Indocyanine green Enzalutamide metabolite M13 Unclear Enzalutamide [1]
MR013693 Indocyanine green Enzalutamide metabolite M4 Unclear Enzalutamide [1]
MR008126 Indocyanine green Indocyanine green metabolite M1 Unclear - Unclear Indocyanine green [2]
MR008127 Indocyanine green Indocyanine green metabolite M2 Unclear - Unclear Indocyanine green [2]
MR008128 Indocyanine green Indocyanine green metabolite M3 Unclear - Unclear Indocyanine green [2]
MR008129 Indocyanine green Indocyanine green metabolite M4 Unclear - Unclear Indocyanine green [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013683 N-desmethyl enzalutamide Carboxyl metabolite enzalutamide (M1) Unclear Enzalutamide [1], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013690 Carboxyl metabolite enzalutamide (M1) Enzalutamide metabolite M5 Unclear Enzalutamide [1]
MR013684 Carboxyl metabolite enzalutamide (M1) Enzalutamide metabolite M11 Conjugation - Acyl glucuronide conjugation Enzalutamide [1]
References
1 Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs
2 Light-induced decomposition of indocyanine green
3 Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide

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