Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013690)
Formula Reactant Carboxyl metabolite enzalutamide (M1) Product Enzalutamide metabolite M5
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013689 Indocyanine green Carboxyl metabolite enzalutamide (M1) Multi-steps Reaction - Amide Hydrolysis; Demethylation Enzalutamide [1], [2]
MR013683 N-desmethyl enzalutamide Carboxyl metabolite enzalutamide (M1) Unclear Enzalutamide [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013684 Carboxyl metabolite enzalutamide (M1) Enzalutamide metabolite M11 Conjugation - Acyl glucuronide conjugation Enzalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013694 Enzalutamide metabolite M4 Enzalutamide metabolite M5 Unclear Enzalutamide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013692 Enzalutamide metabolite M5 Enzalutamide metabolite M12 Conjugation - Acyl glucuronide conjugation Enzalutamide [1]
MR013691 Enzalutamide metabolite M5 Enzalutamide metabolite M17 Conjugation - Taurine conjugation Enzalutamide [1]
References
1 Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs
2 Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide

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