Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013696)
Formula Reactant Opicapone Product BIA 9-1079
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013706 Opicapone BIA 9-1100 Oxidation - Methylation Opicapone [1]
MR013707 Opicapone BIA 9-1101 Multi-steps Reaction - Methylation; reduction Opicapone [1]
MR013704 Opicapone BIA 9-1103 Conjugation - Sulfation Opicapone [1]
MR013705 Opicapone BIA 9-1104 Oxidation - Methylation Opicapone [1]
MR013702 Opicapone BIA 9-1106 Conjugation - Glucuronidation Opicapone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013701 BIA 9-1079 BIA 9-1101 Oxidation - 3\O\methylation Opicapone [2]
MR013697 BIA 9-1079 Opicapone metabolite M41 Unclear Opicapone [2]
References
1 Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor
2 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

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