Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013707)
Formula
SVG example
Methylation; reduction
Reactant Opicapone Product BIA 9-1101
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Methylation; reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013696 Opicapone BIA 9-1079 Reduction - Reduction Opicapone [1]
MR013706 Opicapone BIA 9-1100 Oxidation - Methylation Opicapone [1]
MR013704 Opicapone BIA 9-1103 Conjugation - Sulfation Opicapone [1]
MR013705 Opicapone BIA 9-1104 Oxidation - Methylation Opicapone [1]
MR013702 Opicapone BIA 9-1106 Conjugation - Glucuronidation Opicapone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013701 BIA 9-1079 BIA 9-1101 Oxidation - 3\O\methylation Opicapone [2]
MR013703 BIA 9-1106 BIA 9-1101 Unclear Opicapone [2]
References
1 Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor
2 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

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