Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013907)
Formula
CYP2C9 ...
SVG example
N-desalkylation
Reactant Flunarizine Product Flunarizine M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - N-desalkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013905 Flunarizine Flunarizine M1 Oxidation - N-desalkylation Flunarizine [1]
MR013906 Flunarizine Flunarizine M2 Oxidation - Hydroxylation Flunarizine [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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