Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014115)
Formula
SVG example
Reactant 4-Hydroxybenzoic acid Product 3,4-Dihydroxybenzoic acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008831 Cetraxate PHBA Unclear - Unclear Cetraxate [1]
MR005873 Liquiritin metabolite M9 Liquiritin metabolite M11 Other reaction - Degradation Liquiritin [2]
MR006959 3-(4'-Hydroxyphenyl)acetic acid 4'-Hydroxybenzoic acid Unclear CCG-208408 [3]
MR013576 4'-hydroxyphenylacetic acid 4'-hydroxybenzoic acid Unclear Epigallocatechin gallate [4]
MR004502 4'-Hydroxyphenylacetic acid 4-Hydroxybenzoic acid Unclear VS-12343 [5]
MR004413 4-Hydroxy-4-(4-hydroxyphenyl) butanoic acid 4-Hydroxybenzoic acid Oxidation - Alkyl-chain hydroxylation N-nonylphenol [6]
MR004400 1-(4-hydroxyphenyl)ethanone 4-Hydroxybenzoic acid Unclear N-nonylphenol [6]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005874 Liquiritin metabolite M11 Liquiritin metabolite M13 Other reaction - Amino acid Liquiritin [2]
MR005875 Liquiritin metabolite M11 Liquiritin metabolite M14 Other reaction - Amino acid Liquiritin [2]
MR006960 4'-Hydroxybenzoic acid 4'-Hydroxyhippuric acid Unclear CCG-208408 [3]
MR013577 4'-hydroxybenzoic acid Hippuric acid Unclear Epigallocatechin gallate [4]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012893 4-hydroxylaminobenzoate Protocatechuate Unclear Nitrobenzoate [7]
MR010922 Vanillic acid Protocatechuic acid Unclear - Unclear Isovanillin [8]
MR004360 4-hydroxylaminobenzoate Protocatechuate Unclear Nitrobenzaldehyde [7]
MR004588 DMPE 3,4-Dihydroxybenzoic acid Conjugation - Methylationn Phosethanolamine [9]
MR013910 Mebeverine Metabolite M1 Mebeverine Metabolite M2 Unclear - Unclear Mebeverine [10]
MR013912 Vanillic acid Mebeverine Metabolite M2 Unclear - Unclear Mebeverine [10]
MR004494 3'-4'-Dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear VS-12343 [5]
MR003507 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear L-phenylalanine [11]
MR004402 1-(4-hydroxyphenyl)ethanone 3,4-Dihydroxybenzoic acid Oxidation - Hydrolyzationn N-nonylphenol [6]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012894 Protocatechuate Alpha-hydroxy-gamma-carboxymuconic semialdehyde Other reaction - Ring cleavage reaction Nitrobenzoate [7]
MR010925 Protocatechuic acid Catechol Unclear - Unclear Isovanillin [8]
MR004361 Protocatechuate Nitrobenzaldehyde Metabolite M2 Other reaction - Ring cleavage reaction Nitrobenzaldehyde [7]
MR004495 3,4-Dihydroxybenzoic acid 3-Hydroxybenzoic acid Unclear VS-12343 [5]
References
1 [Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent]
2 A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer
3 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
4 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement
7 Biodegradation of 4-nitrotoluene by Pseudomonas sp. strain 4NT
8 The metabolism of vanillin and isovanillin in the rat
9 Phospholipid N-Methyltransferases Produce Various Methylated Phosphatidylethanolamine Derivatives in Thermophilic Bacteria
10 Investigative implications of the instability and metabolism of mebeverine
11 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.

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