Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004502)
Formula
SVG example
Reactant 4'-Hydroxyphenylacetic acid Product 4-Hydroxybenzoic acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005864 L-tyrosine p-hydroxyphenylacetate Unclear L-tyrosine [1]
MR003838 3-(4-Hydroxyphenyl) propionic acid (4-Hydroxyphenyl) acetic acid Unclear BE-14348A [2]
MR002017 4- hydroxyphenelzine 4-hydroxyphenylacetic acid Hydrolysis - Hydrolysis Phenelzine [3]
MR002016 Phenylacetic acid 4-hydroxyphenylacetic acid Oxidation - 4-Hydroxylation Phenelzine [3]
MR013574 5-(3',4',5'-trihydroxyphenyl)valeric acid 4'-hydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR004501 3-(4'-Hydroxyphenyl)propionic acid 4'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR004398 (2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013575 4'-hydroxyphenylacetic acid 3',4'-dihydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR013582 4'-hydroxyphenylacetic acid 3-methoxy-4'-hydroxyphenlacetic acid Unclear Epigallocatechin gallate [4]
MR004403 2-(4-Hydroxyphenyl)acetic acid (3,4-Dihydroxyphenyl)acetic acid Oxidation - Hydrolyzationn N-nonylphenol [6]
MR004399 2-(4-Hydroxyphenyl)acetic acid 1-(4-hydroxyphenyl)ethanone Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008831 Cetraxate PHBA Unclear - Unclear Cetraxate [7]
MR005873 Liquiritin metabolite M9 Liquiritin metabolite M11 Other reaction - Degradation Liquiritin [8]
MR006959 3-(4'-Hydroxyphenyl)acetic acid 4'-Hydroxybenzoic acid Unclear CCG-208408 [9]
MR004413 4-Hydroxy-4-(4-hydroxyphenyl) butanoic acid 4-Hydroxybenzoic acid Oxidation - Alkyl-chain hydroxylation N-nonylphenol [6]
MR004400 1-(4-hydroxyphenyl)ethanone 4-Hydroxybenzoic acid Unclear N-nonylphenol [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005874 Liquiritin metabolite M11 Liquiritin metabolite M13 Other reaction - Amino acid Liquiritin [8]
MR005875 Liquiritin metabolite M11 Liquiritin metabolite M14 Other reaction - Amino acid Liquiritin [8]
MR006960 4'-Hydroxybenzoic acid 4'-Hydroxyhippuric acid Unclear CCG-208408 [9]
MR013577 4'-hydroxybenzoic acid Hippuric acid Unclear Epigallocatechin gallate [4]
MR014114 4-Hydroxybenzoic acid 3,4-Dihydroxybenzoic acid Oxidation - Alkyl-chain hydroxylation N-nonylphenol [6]
MR014115 4-Hydroxybenzoic acid 3,4-Dihydroxybenzoic acid Unclear N-nonylphenol [6]
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References
1 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
2 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
3 Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
4 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement
7 [Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent]
8 A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer
9 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.

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