Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00001)
Xenobiotics Name
Dimethyl sulfoxide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
679
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [4]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
References
1 Potential use of dimethyl sulfoxide in treatment of infections caused by Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7159-7169.
2 Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal Caco-2 cell model. Toxicol Lett. 2011 Oct 30;206(3):268-75.
3 Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. Biochem J. 2001 Jun 1;356(Pt 2):613-9.
4 Differences in apoptotic signaling and toxicity between dimethylmonothioarsinic acid (DMMTAV) and its active metabolite, dimethylarsinous acid (DMAIII), in HepaRG cells: possibility of apoptosis cascade based on diversity of active metabolites of DMMTAV. J Trace Elem Med Biol. 2018 Dec;50:188-197.
5 Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line. Biochem Biophys Res Commun. 1994 Aug 30;203(1):727-33.

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