Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00280)
Xenobiotics Name
Chlorpromazine hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6240
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [3]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [4]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [4]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [5]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [6]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 34.1 microM [4]
Cytochrome P450 2C9 (CYP2C9) DME Info IC50 > 50 microM [4]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 23.3 microM [4]
References
1 Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases. Toxicol Appl Pharmacol. 1974 Feb;27(2):456-63.
2 Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine. Toxicol In Vitro. 2015 Feb;29(1):221-7.
3 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
4 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.
5 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
6 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.

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