Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00435)
Xenobiotics Name
Urethane
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5641
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [1]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-III (ADH5) DME Info Homo sapiens [3]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [4]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [5]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1], [6]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [4]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [5]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [4]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [4]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [7]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [3]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [4]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [4]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [4]
DOPA decarboxylase (DDC) DME Info Homo sapiens [4]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [3]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [7]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [8]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [9]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [4]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [4]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [10]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [3]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [7]
Alpha-L-iduronidase (IDUA) DME Info Homo sapiens [4]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [4]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [11]
S-adenosylmethionine synthase 1 (MAT1A) DME Info Homo sapiens [11]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [11]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [12]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [4]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [3]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [3]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [3]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [4]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Hydroxyindole O-methyltransferase (ASMT) DME Info Homo sapiens [11]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [11]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [11]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [4]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [7]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [4]
Metallothionein-2A (MT2A) DME Info Homo sapiens [4]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [3]
References
1 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
2 Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. Drug Metab Pharmacokinet. 2002;17(1):42-6.
3 Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq. Toxicol In Vitro. 2018 Feb;46:178-188.
4 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
5 Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett. 2011 Oct 15;3(1):39-42.
6 Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. Drug Metab Dispos. 2005 Aug;33(8):1211-9.
7 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
8 In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver. Xenobiotica. 2003 Jun;33(6):615-23.
9 Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells. Biochem Biophys Res Commun. 2000 May 19;271(3):710-3.
10 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
11 Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish. Aquat Toxicol. 2012 Jun 15;114-115:173-81.
12 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.

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