Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00609)
Xenobiotics Name
MeIQx
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
62275
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [2], [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [5], [1]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [2], [3]
References
1 Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
2 Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells. Food Chem Toxicol. 2012 Mar;50(3-4):949-55.
3 Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food Chem Toxicol. 2013 Sep;59:386-94.
4 Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines. Food Chem Toxicol. 2016 Nov;97:256-264.
5 Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):256-63.

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