Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00610)
Xenobiotics Name
Afimoxifene
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
63062
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [4]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [3]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [6]
Aromatase (CYP19A1) DME Info Homo sapiens [7]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
References
1 Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
2 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
3 Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. Xenobiotica. 2002 Oct;32(10):863-78.
4 The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes. Arch Toxicol. 2018 Mar;92(3):1099-1112.
5 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
6 Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen. Mol Cell Endocrinol. 2010 Jan 15;314(1):90-100.
7 Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res. 2009 Jul 1;69(13):5415-23.

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