Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00632)
Xenobiotics Name
Sodium arsenite
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
443495
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [3]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [3]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [4]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [5]
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [6]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [7]
Amiloride-sensitive amine oxidase (AOC1) DME Info Homo sapiens [7]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [8]
Catalase (CAT) DME Info Homo sapiens [9], [10]
Serine sulfhydrase (CBS) DME Info Homo sapiens [7]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [11]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [12]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [13]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [6]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [11], [14]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [15]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [7]
Dimethylaniline oxidase 2 (FMO2) DME Info Homo sapiens [7]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [7]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [7]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [16]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [17]
S-adenosylmethionine synthase 1 (MAT1A) DME Info Homo sapiens [18]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [7]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [19]
Sulfotransferase 1B1 (SULT1B1) DME Info Homo sapiens [20], [18]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [21]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [18]
Transglutaminase K (TGM1) DME Info Homo sapiens [22]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info Homo sapiens [23]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [21]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [24]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [25], [26]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [27]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [7], [28]
Asparagine synthetase (ASNS) DME Info Homo sapiens [18]
NADPH-dependent carbonyl reductase 1 (CBR1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [29], [30]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [13]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [31], [32]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [33]
Friedreich ataxia protein (FXN) DME Info Homo sapiens [34]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [18]
Glutathione reductase (GSR) DME Info Homo sapiens [35]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [36]
Heparanase (HPSE) DME Info Homo sapiens [37]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [38]
Neprilysin (MME) DME Info Homo sapiens [18]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [7]
Metallothionein-1A (MT1A) DME Info Homo sapiens [39], [40]
Metallothionein-2A (MT2A) DME Info Homo sapiens [41]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [42]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [43]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [44]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [24]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [45]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [27]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [35]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [46]
References
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2 Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol In Vitro. 2011 Mar;25(2):446-53.
3 Inhibitory effects of nitric oxide on the expression and activity of aromatase in human granulosa cells. Mol Hum Reprod. 1999 May;5(5):396-401.
4 Combination therapy of 5-fluorouracil with rapamycin for hormone receptor-negative human breast cancer. Anticancer Res. 2010 Jul;30(7):2625-30.
5 Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. Drug Metab Dispos. 2005 Jul;33(7):993-1003.
6 Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation. Epigenetics. 2013 Oct;8(10):1080-8.
7 Cellular and molecular effects of prolonged low-level sodium arsenite exposure on human hepatic HepaRG cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
8 Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. Chem Res Toxicol. 2013 Jun 17;26(6):926-36.
9 A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb curcuma longa linn. J Clin Biochem Nutr. 2007 Jul;41(1):32-42.
10 Involvement of c-Met- and phosphatidylinositol 3-kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells. Biol Pharm Bull. 2011;34(11):1748-52.
11 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
12 Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis. Toxicol Appl Pharmacol. 2016 Sep 15;307:10-18.
13 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
14 Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. Apoptosis. 2011 Dec;16(12):1268-84.
15 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
16 3,4-Dihydroxybenzaldehyde lowers ROS generation and protects human red blood cells from arsenic(III) induced oxidative damage. Environ Toxicol. 2018 May 6.
17 Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite. Toxicol Appl Pharmacol. 2017 Sep 15;331:130-134.
18 Global alteration of gene expression in human keratinocytes by inorganic arsenic. Carcinogenesis. 2003 Apr;24(4):747-56.
19 Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells. Toxicol Lett. 2017 Feb 15;268:44-50.
20 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
21 Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer. Cancer Sci. 2009 Dec;100(12):2402-10.
22 Keratinocyte differentiation marker suppression by arsenic: mediation by AP1 response elements and antagonism by tetradecanoylphorbol acetate. Toxicol Appl Pharmacol. 2001 Aug 1;174(3):302-11.
23 Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Toxicol Appl Pharmacol. 2001 Jan 15;170(2):93-103.
24 Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. Toxicol Appl Pharmacol. 2009 Sep 1;239(2):162-8.
25 Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci. 2010 Mar;114(1):79-89.
26 Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers. Chem Biol Interact. 2010 Feb 12;183(3):416-24.
27 Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP. Mol Carcinog. 2013 Sep;52(9):676-85.
28 Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation. Arch Toxicol. 2014 Feb;88(2):263-74.
29 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity? Toxicol Sci. 2000 Mar;54(1):121-7.
30 Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect. 2001 Oct;109(10):1027-31.
31 Synergistic antiproliferative and anticholesterogenic effects of linalool, 1,8-cineole, and simvastatin on human cell lines. Chem Biol Interact. 2014 May 5;214:57-68.
32 Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
33 Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study. Toxicol Appl Pharmacol. 2010 Sep 1;247(2):116-28.
34 Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis. 2002 May;23(5):867-76.
35 Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene. Toxicol Lett. 2012 Jun 20;211(3):266-73.
36 Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells. Toxicol Lett. 2019 Oct 1;313:66-76.
37 Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. J Toxicol Sci. 2013;38(3):337-47.
38 Simvastatin modulates the Alzheimer's disease-related gene seladin-1. J Alzheimers Dis. 2012;28(2):297-301.
39 Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients. Ther Drug Monit. 2005 Aug;27(4):539-43.
40 Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc. Arch Toxicol. 2016 Dec;90(12):3029-3044.
41 Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation. Carcinogenesis. 2007 Mar;28(3):639-47.
42 MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. Toxicol Lett. 2017 Aug 15;278:38-47.
43 Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes. Mol Med. 2001 Nov;7(11):767-72.
44 Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):309-17.
45 Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation. Arch Toxicol. 2014 Aug;88(8):1549-59.
46 BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. J Biol Chem. 2008 Aug 15;283(33):22363-70.

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