Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01165)
Xenobiotics Name
CITCO
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
9600409
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [3]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [5]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [6]
References
1 Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. J Pharmacol Exp Ther. 2006 Nov;319(2):693-702.
2 Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Arch Toxicol. 2015 Jan;89(1):57-72.
3 Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep;68(3):747-57.
4 Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor. J Mol Endocrinol. 2011 Sep 7;47(2):229-39.
5 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
6 The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. Dev Biol. 2013 Dec 15;384(2):155-65.

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