Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01176)
Xenobiotics Name
7-hydroxyflavone
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5281894"></iframe>
3D MOL 2D MOL
PubChem CID
5281894
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [7]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aromatase (CYP19A1) DME Info IC50 = 0.0305 microM [3]
Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 0.24 microM [5]
Cytochrome P450 1B1 (CYP1B1) DME Info IC50 = 0.25 microM [6]
References
1 Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. Mol Cell Endocrinol. 2006 Oct 19;259(1-2):30-42.
2 AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
3 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
4 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20;23(12):1921-35.
5 Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2Kinetics analysis, molecular docking, and molecular dynamics simulations. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6008-12.
6 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
7 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.