Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01384)
Xenobiotics Name
Myricetin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
5281672
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3], [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [4]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [4]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A1 (CYP1A1) DME Info Ki = 0.37 microM [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Ki = 0.027 microM [3], [1]
References
1 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem. 2011 May 1;19(9):2842-9.
2 Sulfur mustard downregulates iNOS expression to inhibit wound healing in a human keratinocyte model. J Dermatol Sci. 2008 Mar;49(3):207-16.
3 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
4 Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard. Toxicol Lett. 2014 Nov 4;230(3):393-401.
5 Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes. Microb Pathog. 2017 Jun;107:193-197.

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