Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01455)
Xenobiotics Name
Rhein
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
10168
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [3]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [4]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [5]
Glutamate racemase (MurI) DME Info Streptococcus mutans [4]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [5]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [3]
References
1 Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol Lett. 2019 Jan;300:81-91.
2 Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. Drug Metab Dispos. 2008 Jul;36(7):1322-31.
3 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
4 In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones. Antimicrob Agents Chemother. 2007 Apr;51(4):1541-4.
5 Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm. J Med Microbiol. 2011 Dec;60(Pt 12):1827-1834.

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