Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008991)
Formula
SVG example
Oxidation
Reactant Almogran Product Almogran metabolite P15
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008998 Almogran 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol Oxidation - Oxidation Almogran [1]
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [2]
MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [1]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [1]
MR008999 Almogran Almogran metabolite A1 Oxidation - Oxidative deamination Almogran [3]
MR009000 Almogran Almogran metabolite M5 Oxidation - N-oxidation Almogran [3]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008990 Almogran metabolite A2 Almogran metabolite P15 Unclear - Unclear Almogran [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008992 Almogran metabolite P15 Almogran metabolite P13 Oxidation - N-demethylation Almogran [4]
MR008994 Almogran metabolite P15 Almogran metabolite P23 Oxidation - N-oxidation Almogran [4]
MR008993 Almogran metabolite P15 Almogran metabolite P6 Oxidation - N-dealkylation Almogran [4]
References
1 DrugBank(Pharmacology-Metabolism):Almogran
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.