Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008998)
Formula Reactant Almogran Product 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [1]
MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [2]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [2]
MR008999 Almogran Almogran metabolite A1 Oxidation - Oxidative deamination Almogran [3]
MR009000 Almogran Almogran metabolite M5 Oxidation - N-oxidation Almogran [3]
MR008991 Almogran Almogran metabolite P15 Oxidation - Oxidation Almogran [4]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [2]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 DrugBank(Pharmacology-Metabolism):Almogran
3 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

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