Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009000)
Formula
SVG example
N-oxidation
Reactant Almogran Product Almogran metabolite M5
Reactant Info Product Info
Metabolic Enzyme Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008998 Almogran 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol Oxidation - Oxidation Almogran [1]
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [2]
MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [1]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [1]
MR008999 Almogran Almogran metabolite A1 Oxidation - Oxidative deamination Almogran [3]
MR008991 Almogran Almogran metabolite P15 Oxidation - Oxidation Almogran [4]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [1]
References
1 DrugBank(Pharmacology-Metabolism):Almogran
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.