Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008996)
Formula
MAOA ...
SVG example
Oxidative deamination
Reactant Almogran Product 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Aldehyde dehydrogenase (ALDH) DME Info
Metabolic Type Oxidation - Oxidative deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008998 Almogran 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol Oxidation - Oxidation Almogran [1]
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [2]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [1]
MR008999 Almogran Almogran metabolite A1 Oxidation - Oxidative deamination Almogran [3]
MR009000 Almogran Almogran metabolite M5 Oxidation - N-oxidation Almogran [3]
MR008991 Almogran Almogran metabolite P15 Oxidation - Oxidation Almogran [4]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000144 Almotriptan malate metabolite M1 EX01-008 Other reaction - Dehydration Almotriptan malate [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000145 EX01-008 Almotriptan malate metabolite M8 Conjugation - Conjugation Almotriptan malate [5]
References
1 DrugBank(Pharmacology-Metabolism):Almogran
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.
5 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.

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