Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008999)
Formula Reactant Almogran Product Almogran metabolite A1
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Oxidation - Oxidative deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008998 Almogran 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol Oxidation - Oxidation Almogran [1]
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [2]
MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [1]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [1]
MR009000 Almogran Almogran metabolite M5 Oxidation - N-oxidation Almogran [3]
MR008991 Almogran Almogran metabolite P15 Oxidation - Oxidation Almogran [4]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [1]
References
1 DrugBank(Pharmacology-Metabolism):Almogran
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

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