Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00547)
Xenobiotics Name
Vitamin E
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
14985
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Gastric alcohol dehydrogenase (ADH7) DME Info Homo sapiens [1]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [2], [3]
Azoreductase (azoR) DME Info Escherichia coli [4]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [4]
Beta-lactamase (blaB) DME Info Escherichia coli [4]
Chloramphenicolase (chlR) DME Info Escherichia coli [4]
Glycoside hydrolase (cscA) DME Info Escherichia coli [4]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [5], [3]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [4]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [4]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [4]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [4]
Glutamate racemase (MurI) DME Info Escherichia coli [4]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [4]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [6]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [4]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [4]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [4]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [7]
Tyramine oxidase (tynA) DME Info Escherichia coli [4]
Beta-glucuronidase (uidA) DME Info Escherichia coli [4]
DME(s) Induced by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [8]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [9], [5]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [5]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [9]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [10], [9]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [9]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [9]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [9]
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME Info Homo sapiens [5]
References
1 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
3 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
4 Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats. Infect Immun. 2011 Dec;79(12):4819-27.
5 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
6 Identification of alpha-tocopherol as a bioactive component of Dicranopteris linearis with disrupting property against preformed biofilm of Staphylococcus aureus. J Appl Microbiol. 2017 Nov;123(5):1148-1159.
7 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
8 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
9 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
10 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.

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