Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00683)
Xenobiotics Name
Curcumin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
969516
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [1]
Beta-lactamase (blaB) DME Info Citrobacter freundii [2]
Beta-lactamase (blaB) DME Info Serratia marcescens [3]
Azoreductase (azoR) DME Info Escherichia coli [3]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [3]
Beta-lactamase (blaB) DME Info Escherichia coli [3]
NADPH-dependent carbonyl reductase 1 (CBR1) DME Info Homo sapiens [4]
Chloramphenicolase (chlR) DME Info Escherichia coli [3]
Carbapenemase (cphA) DME Info Aeromonas hydrophila [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [3]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5], [6]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [6]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [8]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [3]
Unclear metabolic mechanism (DME-unclear) DME Info Citrobacter freundii [2]
Unclear metabolic mechanism (DME-unclear) DME Info Enterobacter cancerogenus [2]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [9]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [10]
Insulin-degrading enzyme (ide) DME Info Vibrio vulnificus [11]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [12]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [3]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [3]
Neprilysin (MME) DME Info Homo sapiens [13]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [3]
Myeloperoxidase (MPO) DME Info Homo sapiens [14]
Glutamate racemase (MurI) DME Info Escherichia coli [3]
Glutamate racemase (MurI) DME Info Streptococcus mutans [9]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [13]
Arylamine N-acetyltransferase (NAT) DME Info Serratia marcescens [3]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [3]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [3]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [3]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [3]
Arylamine N-acetyltransferase (NAT) DME Info Citrobacter freundii [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [3]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [3]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [8]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [15]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [16]
Tyramine oxidase (tynA) DME Info Escherichia coli [3]
Beta-glucuronidase (uidA) DME Info Escherichia coli [3]
DME(s) Induced by This Xenobiotics
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [17]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [18]
Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info Homo sapiens [19]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [20]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [21], [13]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [22]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [22]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.
3 Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa. Food Chem. 2014 Apr 1;148:453-60.
4 Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1. Chem Biol Interact. 2015 Jun 5;234:162-8.
5 Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR). Chem Res Toxicol. 2012 Sep 17;25(9):1878-84.
6 Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells. Mol Nutr Food Res. 2005 Jun;49(6):585-93.
7 Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. J Pharm Pharmacol. 2007 Jun;59(6):857-62.
8 Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
9 Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity. Arch Oral Biol. 2013 Oct;58(10):1343-8.
10 Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78.
11 Prevention of quorum-sensing-mediated biofilm development and virulence factors production in Vibrio sppby curcumin. Appl Microbiol Biotechnol. 2013 Dec;97(23):10177-87.
12 Curcumin downregulates H19 gene transcription in tumor cells. J Cell Biochem. 2008 Aug 1;104(5):1781-92.
13 Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp Hematol. 2007 Jan;35(1):84-95.
14 Intra- and extracellular antioxidant capacities of the new water-soluble form of curcumin (NDS27) on stimulated neutrophils and HL-60 cells. Chem Biol Interact. 2013 Jan 25;201(1-3):49-57.
15 Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer. 2008 Jan 15;122(2):267-73.
16 Synergistic effect of curcumin and cisplatin via down-regulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1). Mol Pharmacol. 2011 Jul;80(1):136-46.
17 Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem. 2010 Dec;21(12):1153-61.
18 Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem. 2007 Feb;18(2):113-9.
19 Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3293-302.
20 Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):726-35.
21 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
22 Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. Biol Pharm Bull. 2006 Jul;29(7):1476-9.

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