Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1069)
DME Name Nicotinate dehydrogenase (nicA), Pseudomonas putida DME Info
UniProt ID
NICA_PSEPK
EC Number    EC: 1.17.2.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
MCD acceptor oxidoreductase
EC: 1.17.2.1
Lineage    Species: Pseudomonas putida     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas putida
Subspecies: Pseudomonas putida S16
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Nicotine Click to Show/Hide the Full List of HOSPPI:      12 HOSPPI
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 1A1 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 1A2 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A13 (CYP2A13) Click to Show/Hide the Cometabolization Info
DME ID DME0030 DME Info
Uniprot ID
CP2AD_HUMAN
Interaction Name CYP2A13-nicA interaction [1], [3]
Description The interaction, between human Cytochrome P450 2A13 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-nicA interaction [1], [4]
Description The interaction, between human Cytochrome P450 2A6 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-nicA interaction [1], [5]
Description The interaction, between human Cytochrome P450 2B6 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2C8 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2C9 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2D6 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-nicA interaction [1], [6]
Description The interaction, between human Cytochrome P450 2E1 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-nicA interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-nicA interaction [1], [2]
Description The interaction, between human Mephenytoin 4-hydroxylase and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-nicA interaction [1], [7]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Nicotinate dehydrogenase from Pseudomonas putida which collectively metabolize the drug Nicotine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
2 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
3 Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. J Pharmacol Exp Ther. 2006 Jan;316(1):295-303.
4 CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine delta-5'(1')iminium ion. J Pharmacol Exp Ther. 2012 Nov;343(2):307-15.
5 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos. 2005 Dec;33(12):1760-4.
6 Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9.
7 Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition. J Pharm Biomed Anal. 2011 Jul 15;55(5):964-71.

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