Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1075)
DME Name Cytochrome P450 102A1 (cyp102), Bacillus megaterium DME Info
UniProt ID
CPXB_BACMB
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: CCRIS-9277 Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Catechol O-methyltransferase (COMT) Click to Show/Hide the Cometabolization Info
DME ID DME0043 DME Info
Uniprot ID
COMT_HUMAN
Interaction Name COMT-cyp102 interaction [1], [2]
Description The interaction, between human Catechol O-methyltransferase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug CCRIS-9277, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [1], [2]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug CCRIS-9277, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Diclofenac sodium Click to Show/Hide the Full List of HOSPPI:      12 HOSPPI
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp102 interaction [3], [4]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp102 interaction [3], [6]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp102 interaction [3], [13]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp102 interaction [3], [17]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C18 (CYP2C18) Click to Show/Hide the Cometabolization Info
DME ID DME0017 DME Info
Uniprot ID
CP2CI_HUMAN
Interaction Name CYP2C18-cyp102 interaction [3], [6]
Description The interaction, between human Cytochrome P450 2C18 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp102 interaction [3], [21]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp102 interaction [3], [23]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [3], [37]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp102 interaction [3], [6]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A3 (UGT1A3) Click to Show/Hide the Cometabolization Info
DME ID DME0041 DME Info
Uniprot ID
UD13_HUMAN
Interaction Name UGT1A3-cyp102 interaction [3], [51]
Description The interaction, between human UDP-glucuronosyltransferase 1A3 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A9 (UGT1A9) Click to Show/Hide the Cometabolization Info
DME ID DME0042 DME Info
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-cyp102 interaction [3], [51]
Description The interaction, between human UDP-glucuronosyltransferase 1A9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 2B7 (UGT2B7) Click to Show/Hide the Cometabolization Info
DME ID DME0040 DME Info
Uniprot ID
UD2B7_HUMAN
Interaction Name UGT2B7-cyp102 interaction [3], [55]
Description The interaction, between human UDP-glucuronosyltransferase 2B7 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Dextromethorphan hydrobromide Click to Show/Hide the Full List of HOSPPI:        8 HOSPPI
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp102 interaction [1], [4]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp102 interaction [1], [18]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp102 interaction [1], [25]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [1], [29]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [1], [38]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp102 interaction [1], [24]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp102 interaction [1], [42]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp102 interaction [1], [25]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Amodiaquine Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp102 interaction [1], [5]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Amodiaquine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1B1 (CYP1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0023 DME Info
Uniprot ID
CP1B1_HUMAN
Interaction Name CYP1B1-cyp102 interaction [1], [5]
Description The interaction, between human Cytochrome P450 1B1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Amodiaquine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp102 interaction [1], [19]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Amodiaquine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase mu-4 (GSTM4) Click to Show/Hide the Cometabolization Info
DME ID DME0613 DME Info
Uniprot ID
GSTM4_HUMAN
Interaction Name GSTM4-cyp102 interaction [1], [45]
Description The interaction, between human Glutathione S-transferase mu-4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Amodiaquine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Acetaminophen Click to Show/Hide the Full List of HOSPPI:      14 HOSPPI
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp102 interaction [1], [7]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp102 interaction [1], [14]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-cyp102 interaction [1], [16]
Description The interaction, between human Cytochrome P450 2A6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp102 interaction [1], [24]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [1], [16]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-cyp102 interaction [1], [31]
Description The interaction, between human Cytochrome P450 2E1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [1], [16]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp102 interaction [1], [41]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase alpha-1 (GSTA1) Click to Show/Hide the Cometabolization Info
DME ID DME0011 DME Info
Uniprot ID
GSTA1_HUMAN
Interaction Name GSTA1-cyp102 interaction [1], [44]
Description The interaction, between human Glutathione S-transferase alpha-1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-cyp102 interaction [1], [47]
Description The interaction, between human Sulfotransferase 1A1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-cyp102 interaction [1], [50]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A6 (UGT1A6) Click to Show/Hide the Cometabolization Info
DME ID DME0072 DME Info
Uniprot ID
UD16_HUMAN
Interaction Name UGT1A6-cyp102 interaction [1], [52]
Description The interaction, between human UDP-glucuronosyltransferase 1A6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A9 (UGT1A9) Click to Show/Hide the Cometabolization Info
DME ID DME0042 DME Info
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-cyp102 interaction [1], [53]
Description The interaction, between human UDP-glucuronosyltransferase 1A9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 2B15 (UGT2B15) Click to Show/Hide the Cometabolization Info
DME ID DME0049 DME Info
Uniprot ID
UDB15_HUMAN
Interaction Name UGT2B15-cyp102 interaction [1], [54]
Description The interaction, between human UDP-glucuronosyltransferase 2B15 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Acetaminophen, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Chlorzoxazone Click to Show/Hide the Full List of HOSPPI:        5 HOSPPI
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp102 interaction [8], [1], [9]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Chlorzoxazone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-cyp102 interaction [8], [1], [15]
Description The interaction, between human Cytochrome P450 2A6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Chlorzoxazone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [8], [1], [15]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Chlorzoxazone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-cyp102 interaction [8], [1], [30]
Description The interaction, between human Cytochrome P450 2E1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Chlorzoxazone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [8], [1], [24]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Chlorzoxazone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nifedipine Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp102 interaction [8], [1], [10]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Nifedipine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [8], [1], [27]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Nifedipine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [8], [1], [33]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Nifedipine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp102 interaction [8], [1], [39]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Nifedipine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Propranolol hydrochloride Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp102 interaction [11], [12]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [11], [28]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [11], [34]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp102 interaction [11], [40]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp102 interaction [11], [40]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dimethylaniline oxidase 2 (FMO2) Click to Show/Hide the Cometabolization Info
DME ID DME0283 DME Info
Uniprot ID
FMO2_HUMAN
Interaction Name FMO2-cyp102 interaction [11], [43]
Description The interaction, between human Dimethylaniline oxidase 2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp102 interaction [11], [46]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Propranolol hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Mefenamic acid Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp102 interaction [3], [20]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Mefenamic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp102 interaction [3], [22]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Mefenamic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Buspirone Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp102 interaction [1], [11], [26]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Buspirone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [1], [11], [32]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Buspirone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp102 interaction [1], [11], [26]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Buspirone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp102 interaction [1], [11], []
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Buspirone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: GEA-6414 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [3], [35]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug GEA-6414, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Benzyloxyresorufin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp102 interaction [1], [36]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Benzyloxyresorufin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Mononitrophenol Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Sulfotransferase 1A2 (SULT1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0062 DME Info
Uniprot ID
ST1A2_HUMAN
Interaction Name SULT1A2-cyp102 interaction [8], [1], [48]
Description The interaction, between human Sulfotransferase 1A2 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Mononitrophenol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1B1 (SULT1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0380 DME Info
Uniprot ID
ST1B1_HUMAN
Interaction Name SULT1B1-cyp102 interaction [8], [1], [49]
Description The interaction, between human Sulfotransferase 1B1 and Cytochrome P450 102A1 from Bacillus megaterium which collectively metabolize the drug Mononitrophenol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
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