Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0218)
DME Name Steroid 5-alpha-reductase 2 (SRD5A2), Homo sapiens DME Info
UniProt ID
S5A2_HUMAN
EC Number    EC: 1.3.1.22     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.22
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Fungicide(s), Herbicide(s) or Insecticide(s)
                  Fungicide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Fenarimol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00946   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Fenarimol inhibits the drug-metabolizing activity of DME SRD5A2 [1]
                              Prochloraz Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00955   XEOTIC Info Gene Form Protein
                                 Classification Fungicide
                                 DME Modulation Prochloraz inhibits the drug-metabolizing activity of DME SRD5A2 [2]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cadmium Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01503   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Cadmium up-regulates the expression of DME SRD5A2 [3]
                              Piperidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01432   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Piperidine inhibits the drug-metabolizing activity of DME SRD5A2 [4], [5]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Aflatoxin B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00806   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen-mycotoxin
                                 DME Modulation Aflatoxin B1 inhibits the expression of DME SRD5A2 [6]
                  Environmental Pollutant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Dichlorodiphenyl dichloroethylene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00768   XEOTIC Info Gene Form Protein
                                 Classification Environmental Pollutant
                                 DME Modulation Dichlorodiphenyl dichloroethylene inhibits the drug-metabolizing activity of DME SRD5A2 [1]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Osajin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01570   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Osajin inhibits the drug-metabolizing activity of DME SRD5A2 [7]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Cyclosporine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00241   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Cyclosporine inhibits the expression of DME SRD5A2 [8]
                              Dutasteride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00192   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Dutasteride inhibits the expression of DME SRD5A2 [9]
                              Estradiol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00090   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Estradiol inhibits the expression of DME SRD5A2 [8]
                              Finasteride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00129   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Finasteride inhibits the drug-metabolizing activity of DME SRD5A2 (IC50 < 0.0001 microM) [10], [11]
                              Flutamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00038   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Flutamide inhibits the drug-metabolizing activity of DME SRD5A2 [1]
                              Zoledronic acid Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00140   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Zoledronic acid up-regulates the expression of DME SRD5A2 [12], [13]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the expression of DME SRD5A2 [14]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Chlorogenic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01246   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Chlorogenic acid inhibits the expression of DME SRD5A2 [14]
                              Genistein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00557   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Genistein inhibits the expression of DME SRD5A2 [14]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pregnadienes Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00815   XEOTIC Info Gene Form mRNA
                                 Classification Chemical Compound
                                 DME Modulation Pregnadienes inhibits the expression of DME SRD5A2 [15]
References
1 Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells. Toxicol In Vitro. 2007 Apr;21(3):502-8.
2 Hexavalent chromium-induced alteration of proteomic landscape in human skin fibroblast cells. J Proteome Res. 2013 Jul 5;12(7):3511-8.
3 Microarray analysis of gene expression patterns in human proximal tubule cells over a short and long time course of cadmium exposure. J Toxicol Environ Health A. 2011;74(1):24-42.
4 Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63.
5 Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters. J Toxicol Environ Health A. 1998 Mar 13;53(5):385-99.
6 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
7 A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55.
8 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
9 Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):129-40.
10 4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductasesDramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency. J Med Chem. 1995 Aug 18;38(17):3189-92.
11 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem. 1994 Nov 11;37(23):3871-4.
12 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
13 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
14 Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010.
15 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.

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