Detail Information of Xenobiotics
| General Information of Xenobiotics (ID: XEO01824) | ||||||
|---|---|---|---|---|---|---|
| Xenobiotics Name |
TL(3)[Pro3,DLeu9]
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| Xenobiotics Type |
Amino Acid(s), Peptide(s) or Protein(s)
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| Classification |
Peptide
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| DME(s) Modulated by This Xenobiotics | ||||||
| DME(s) Inhibited by This Xenobiotics | ||||||
| Aminoglycoside N-acetyltransferase (aacC2) | DME Info | Acinetobacter baumannii | [1] | |||
| Aminoglycoside O-phosphotransferase (aphA6) | DME Info | Acinetobacter baumannii | [1] | |||
| Azoreductase (azoR) | DME Info | Escherichia coli | [1] | |||
| L,D-carboxypeptidase A (ldcA) | DME Info | Escherichia coli | [1] | |||
| Beta-lactamase (blaB) | DME Info | Escherichia coli | [1] | |||
| Beta-lactamase (blaB) | DME Info | Acinetobacter baumannii | [1] | |||
| Chloramphenicolase (chlR) | DME Info | Escherichia coli | [1] | |||
| Glycoside hydrolase (cscA) | DME Info | Escherichia coli | [1] | |||
| NADPH-dependent curcumin reductase (curA) | DME Info | Escherichia coli | [1] | |||
| Cytochrome P450 102A1 (cyp102) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 MEG (cyp106) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 21A2 (cyp21) | DME Info | Bacillus megaterium | [1] | |||
| Cytochrome P450 BM3 (cypBM3) | DME Info | Bacillus megaterium | [1] | |||
| Unclear metabolic mechanism (DME-unclear) | DME Info | Escherichia coli | [1] | |||
| Glutamate decarboxylase (gadB) | DME Info | Escherichia coli | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | Escherichia coli | [1] | |||
| Molybdopterin-dependent enzyme (molD) | DME Info | Escherichia coli | [1] | |||
| Glutamate racemase (MurI) | DME Info | Escherichia coli | [1] | |||
| N-ethylmaleimide reductase (nemA) | DME Info | Escherichia coli | [1] | |||
| Oxygen-insensitive NADPH nitroreductase A (nfsA) | DME Info | Escherichia coli | [1] | |||
| Oxygen-insensitive NADPH nitroreductase B (nfsB) | DME Info | Escherichia coli | [1] | |||
| NADH dehydrogenase (nuoE) | DME Info | Streptomyces griseus | [1] | |||
| Nicotinamidase (pncA) | DME Info | Acinetobacter baumannii | [1] | |||
| Tyramine oxidase (tynA) | DME Info | Escherichia coli | [1] | |||
| Beta-glucuronidase (uidA) | DME Info | Escherichia coli | [1] | |||
| Xenobiotics-DME Activity Data | ||||||
| Xenobiotics-DME Activity Data | Aminoglycoside N-acetyltransferase (aacC2) | DME Info | MIC = 50 microM | [1] | ||
| Aminoglycoside O-phosphotransferase (aphA6) | DME Info | MIC = 50 microM | [1] | |||
| Azoreductase (azoR) | DME Info | MIC = 50 microM | [1] | |||
| L,D-carboxypeptidase A (ldcA) | DME Info | MIC = 50 microM | [1] | |||
| Beta-lactamase (blaB) | DME Info | MIC = 50 microM | [1] | |||
| Beta-lactamase (blaB) | DME Info | MIC = 50 microM | [1] | |||
| Chloramphenicolase (chlR) | DME Info | MIC = 50 microM | [1] | |||
| Glycoside hydrolase (cscA) | DME Info | MIC = 50 microM | [1] | |||
| NADPH-dependent curcumin reductase (curA) | DME Info | MIC = 50 microM | [1] | |||
| Cytochrome P450 102A1 (cyp102) | DME Info | MIC = 3.125 microM | [1] | |||
| Cytochrome P450 MEG (cyp106) | DME Info | MIC = 3.125 microM | [1] | |||
| Cytochrome P450 21A2 (cyp21) | DME Info | MIC = 3.125 microM | [1] | |||
| Cytochrome P450 BM3 (cypBM3) | DME Info | MIC = 3.125 microM | [1] | |||
| Unclear metabolic mechanism (DME-unclear) | DME Info | MIC = 50 microM | [1] | |||
| Glutamate decarboxylase (gadB) | DME Info | MIC = 50 microM | [1] | |||
| D-Lactate dehydrogenase (ldhA) | DME Info | MIC = 50 microM | [1] | |||
| Molybdopterin-dependent enzyme (molD) | DME Info | MIC = 50 microM | [1] | |||
| Glutamate racemase (MurI) | DME Info | MIC = 50 microM | [1] | |||
| N-ethylmaleimide reductase (nemA) | DME Info | MIC = 50 microM | [1] | |||
| Oxygen-insensitive NADPH nitroreductase A (nfsA) | DME Info | MIC = 50 microM | [1] | |||
| Oxygen-insensitive NADPH nitroreductase B (nfsB) | DME Info | MIC = 50 microM | [1] | |||
| NADH dehydrogenase (nuoE) | DME Info | MIC = 50 microM | [1] | |||
| Nicotinamidase (pncA) | DME Info | MIC = 50 microM | [1] | |||
| Tyramine oxidase (tynA) | DME Info | MIC = 50 microM | [1] | |||
| Beta-glucuronidase (uidA) | DME Info | MIC = 50 microM | [1] | |||
| References | ||||||
| 1 | Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities. Eur J Med Chem. 2017 Oct 20;139:750-761. | |||||
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