Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01366)
Xenobiotics Name
Linalool
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
6549
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aminoglycoside N-acetyltransferase (aacC2) DME Info Acinetobacter baumannii [1]
Aminoglycoside O-phosphotransferase (aphA6) DME Info Acinetobacter baumannii [1]
Azoreductase (azoR) DME Info Escherichia coli [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [2]
Beta-lactamase (blaB) DME Info Escherichia coli [2]
Beta-lactamase (blaB) DME Info Acinetobacter baumannii [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [2]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [3]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [2]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [2]
Glutamate racemase (MurI) DME Info Escherichia coli [2]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [2]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [2]
Nicotinamidase (pncA) DME Info Acinetobacter baumannii [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [2]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [6]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [5]
References
1 Study of the major essential oil compounds of Coriandrum sativum against Acinetobacter baumannii and the effect of linalool on adhesion, biofilms and quorum sensing. Biofouling. 2016;32(2):155-65.
2 Anti-biofilm forming and anti-quorum sensing activity of selected essential oils and their main components on food-related micro-organisms. J Appl Microbiol. 2013 Oct;115(4):933-42.
3 Synergistic antiproliferative and anticholesterogenic effects of linalool, 1,8-cineole, and simvastatin on human cell lines. Chem Biol Interact. 2014 May 5;214:57-68.
4 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
5 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
6 Editor's highlight: fragrance allergens linalool and limonene allylic hydroperoxides in skin allergy: Mechanisms of action focusing on transcription factor Nrf2. Toxicol Sci. 2018 Jan 1;161(1):139-148.

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