Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012736)
Formula
SMS
SVG example
Unclear
Reactant Spermidine Product Spermine
Reactant Info Product Info
Metabolic Enzyme Spermine synthase (SMS) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003936 KM-1406 SPD Oxidation - Oxidationn KM-1406 [1]
MR007654 Putrescine Spermidine Other reaction - N-Decarboxylation Putrescine [2]
MR003934 AcSPM SPD Unclear KM-1406 [1]
MR003067 Putrescine Spermidine Unclear Agmatine [3], [4], [5]
MR012735 Putrescine Spermidine Unclear - Unclear Arginine [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003935 SPD AcSPD N1-acetylspermidine Unclear KM-1406 [1]
MR003071 Spermidine MTA Unclear Agmatine [3]
MR003070 Spermidine N1-AcSpd Unclear Agmatine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000578 CCG-205124 Spermine Unclear CCG-205124 [7]
MR007653 Putrescine Spermine Other reaction - Decarboxylation Putrescine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000575 Spermine N--Acetylspermine Unclear CCG-205124 [7]
MR003069 Spermine N-AcSpm Unclear Agmatine [3]
References
1 Spermine metabolism and anticancer therapy
2 Human aldehyde dehydrogenase: metabolism of putrescine and histamine
3 Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine Amino Acids. 2004 Feb;26(1):3-8. doi: 10.1007/s00726-003-0030-z.
4 Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought. BMC Genomics. 2022 Oct 30;23(1):734. doi: 10.1186/s12864-022-08946-2.
5 Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body. Biomolecules. 2022 Mar 25;12(4):501. doi: 10.3390/biom12040501.
6 Arginine Metabolism Revisited
7 The Association between Spermidine/Spermine N(1)-Acetyltransferase (SSAT) and Human Malignancies Int J Mol Sci. 2022 May 25;23(11):5926. doi: 10.3390/ijms23115926.

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