Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000155)
Formula
CYP1A2 ...
SVG example
N-Demethylation
Reactant Almotriptan malate Product LAS 31612
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000152 Almotriptan malate Almotriptan malate metabolite M1 Oxidation - Oxidative Deamination Almotriptan malate [1]
MR000153 Almotriptan malate Almotriptan malate metabolite M3 Oxidation - Pyrrolidine Oxidation Almotriptan malate [1]
MR000156 Almotriptan malate Almotriptan malate metabolite M7 Oxidation - Deamination Almotriptan malate [2]
MR000154 Almotriptan malate LAS 32195 Oxidation - N-Oxidation Almotriptan malate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [3]
References
1 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
2 Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
3 DrugBank(Pharmacology-Metabolism):Almogran

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